Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options

被引:81
作者
Zumla, Alimuddin [1 ,2 ,3 ,4 ]
Memish, Ziad A. [4 ,5 ]
Maeurer, Markus [6 ,7 ]
Bates, Matthew [1 ,3 ]
Mwaba, Peter [3 ]
Al-Tawfiq, Jaffar A. [8 ,9 ]
Denning, David W. [10 ]
Hayden, Frederick G. [11 ]
Hui, David S. [12 ,13 ]
机构
[1] UCL, Div Infect & Immun, London, England
[2] Univ Coll London Hosp, NIHR Biomed Res Ctr, London, England
[3] Univ Zambia, Univ Coll London, Res & Training Project, Univ Teaching Hosp, Lusaka, Zambia
[4] Minist Hlth, Global Ctr Mass Gatherings Med, Riyadh, Saudi Arabia
[5] Al Faisal Univ, Riyadh, Saudi Arabia
[6] Karolinska Inst, Dept Lab Med, Stockholm, Sweden
[7] Karolinska Inst, Dept Microbiol Tumour & Cell Biol, Stockholm, Sweden
[8] Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia
[9] Indiana Univ Sch Med, Indianapolis, IN 46202 USA
[10] Univ S Manchester, Univ S Manchester Hosp, Natl Aspergillosis Ctr, Acad Hlth Sci Ctr, Manchester, Lancs, England
[11] Univ Virginia, Sch Med, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA
[12] Chinese Univ Hong Kong, Prince Wales Hosp, Div Resp Med, Hong Kong, Hong Kong, Peoples R China
[13] Chinese Univ Hong Kong, Prince Wales Hosp, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China
基金
瑞典研究理事会;
关键词
CRITICALLY-ILL PATIENTS; A DOUBLE-BLIND; INFLUENZA-A; ASPERGILLUS-FUMIGATUS; T-CELLS; VIRUS-INFECTION; IN-VITRO; SYNDROME CORONAVIRUS; H1N1; VIRUS; OPEN-LABEL;
D O I
10.1016/S1473-3099(14)70828-X
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The emergence and spread of antimicrobial-resistant bacterial, viral, and fungal pathogens for which diminishing treatment options are available is of major global concern. New viral respiratory tract infections with epidemic potential, such as severe acute respiratory syndrome, swine-origin influenza A H1N1, and Middle East respiratory syndrome coronavirus infection, require development of new antiviral agents. The substantial rise in the global numbers of patients with respiratory tract infections caused by pan-antibiotic-resistant Gram-positive and Gram-negative bacteria, multidrug-resistant Mycobacterium tuberculosis, and multiazole-resistant fungi has focused attention on investments into development of new drugs and treatment regimens. Successful treatment outcomes for patients with respiratory tract infections across all health-care settings will necessitate rapid, precise diagnosis and more effective and pathogen-specific therapies. This Series paper describes the development and use of new antimicrobial agents and immune-based and host-directed therapies for a range of conventional and emerging viral, bacterial, and fungal causes of respiratory tract infections.
引用
收藏
页码:1136 / 1149
页数:14
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