Intranasal immunization against influenza

被引：18

作者：

Glück, R ^{[1
]}

机构：

[1] Berna Biotech Ltd, CH-3018 Bern, Switzerland

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 2002年 / 15卷 / 02期

关键词：

influenza vaccine; intranasal immunization; virosomol vaccine; HLT (Escherigan Berna); local immune response;

D O I：

10.1089/089426802320282347

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Nasalflu is a novel influenza subunit vaccine, which is administered by the intranasal route using a spray device. Nasalflu is based on the virosomal concept which is registered in the EU as Epaxal Berna, a vaccine against Hepatitis A, and Inflexal Berna V, a subunit influenza vaccine. The virosome is a carrier system which delivers antigens to cells and is able to induce both B- and T-cell immunity. When virosomal vaccines are given parenterally, an immune response is elicited fast and sufficiently.

引用

页码：221 / 228

页数：8

共 35 条

[1] REDUCTION IN MORTALITY ASSOCIATED WITH INFLUENZA VACCINE DURING 1989-90 EPIDEMIC
AHMED, AEH
NICHOLSON, KG
NGUYENVANTAM, JS
[J]. LANCET, 1995, 346 (8975): : 591 - 595
[2] ALEXANDROVA G. I., 1965, REV ROUMAINE INFRAMICROBIOL, V2, P179
[3] SAFETY AND IMMUNOGENICITY OF A PROTOTYPE ORAL WHOLE-CELL KILLED CAMPYLOBACTER VACCINE ADMINISTERED WITH A MUCOSAL ADJUVANT IN NONHUMAN-PRIMATES
BAQAR, S
BOURGEOIS, AL
SCHULTHEISS, PJ
WALKER, RI
ROLLINS, DM
HABERBERGER, RL
PAVLOVSKIS, OR
[J]. VACCINE, 1995, 13 (01) : 22 - 28
[4] The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children
Belshe, RB
Mendelman, PM
Treanor, J
King, J
Gruber, WC
Piedra, P
Bernstein, DI
Hayden, FG
Kotloff, K
Zangwill, K
Iacuzio, D
Wolff, M
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (20) : 1405 - 1412
[5] FUSION ACTIVITY OF INFLUENZA VIRUS-PR8/34 CORRELATES WITH A TEMPERATURE-INDUCED CONFORMATIONAL CHANGE WITHIN THE HEMAGGLUTININ ECTODOMAIN DETECTED BY PHOTOCHEMICAL LABELING
BRUNNER, J
ZUGLIANI, C
MISCHLER, R
[J]. BIOCHEMISTRY, 1991, 30 (09) : 2432 - 2438
[6] The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)
Cheng, E
Cárdenas-Freytag, L
Clements, JD
[J]. VACCINE, 1999, 18 (1-2) : 38 - 49
[7] SERUM AND NASAL WASH ANTIBODIES ASSOCIATED WITH RESISTANCE TO EXPERIMENTAL CHALLENGE WITH INFLUENZA-A WILD-TYPE VIRUS
CLEMENTS, ML
BETTS, RF
TIERNEY, EL
MURPHY, BR
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 24 (01) : 157 - 160
[8] MUTANTS OF ESCHERICHIA-COLI HEAT-LABILE TOXIN LACKING ADP-RIBOSYLTRANSFERASE ACTIVITY ACT AS NONTOXIC, MUCOSAL ADJUVANTS
DOUCE, G
TURCOTTE, C
CROPLEY, I
ROBERTS, M
PIZZA, M
DOMENGHINI, M
RAPPUOLI, R
DOUGAN, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1644 - 1648
[9] H+-induced membrane insertion of influenza virus hemagglutinin involves the HA2 amino-terminal fusion peptide but not the coiled coil region
Durrer, P
Galli, C
Hoenke, S
Corti, C
Gluck, R
Vorherr, T
Brunner, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) : 13417 - 13421
[10] ELSON CO, 1984, J IMMUNOL, V132, P2736

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