Neuroprotection by propargylamines in Parkinson's disease - Suppression of apoptosis and induction of prosurvival genes

被引:131
作者
Maruyama, W [1 ]
Akao, Y
Carrillo, MC
Kitani, K
Youdium, MBH
Naoi, M
机构
[1] Natl Inst Longev Sci, Dept Basic Gerontol, Biochem & Metab Lab, Aichi 4748522, Japan
[2] Gifu Int Inst Biotechnol, Mitake, Gifu, Japan
[3] Univ Nacl Rosario, Rosario, Argentina
[4] Technion Israel Inst Technol, Fac Med, Dept Pharmacol, Eve Topf & NPF Ctr, IL-32000 Haifa, Israel
[5] Inst Appl Biochem, Mitake, Gifu, Japan
基金
日本学术振兴会;
关键词
rasagiline; apoptosis; N-methyl(R)salsolinol; Parkinson's disease; mitochondrial permeability transition; dopamine neuron;
D O I
10.1016/S0892-0362(02)00221-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In Parkinson's disease (PD), therapies to delay or suppress the progression of cell death in nigrostriatal dopamine neurons have been proposed by use of various agents. An inhibitor of type B monoamine oxidase (MAO-B), (-)deprenyl (selegiline), was reported to have neuroprotective activity, but clinical trials failed to confirm it. However, the animal and cellular models of PD proved that selegiline protects neurons from cell death. Among selegiline-related propargylamines, (R)(+)-N-propargyl-1-aminoindan (rasagiline) was the most effective to suppress the cell death in in vivo and in vitro experiments. In this paper, the mechanism of the neuroprotection by rasagiline was examined using human dopaminergic SH-SY5Y cells against cell death induced by an endogenous dopaminergic neurotoxin N-methyl(R)salsolinol (NM(R)Sal). NM(R)Sal induced apoptosis (but not necrosis) in SH-SY5Y cells, and the apoptotic cascade was initiated by mitochondrial permeability transition (PT) and activated by stepwise reactions. Rasagiline prevented the PT in mitochondria directly and also indirectly through induction of antiapoptotic Bcl-2 and a neurotrophic factor, glial cell line-derived neurotrophic factor (GDNF). Long-term administration of propargylamines to rats increased the activities of antioxidative enzymes superoxide dismutase (SOD) and catalase in the brain regions containing dopamine neurons. Rasagiline and related propargylamines may rescue degenerating dopamine neurons through inhibiting death signal transduction initiated by mitochondria PT. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:675 / 682
页数:8
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