PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum .2. Physico-chemical properties and structure elucidation

被引：17

作者：

Tabata, Y

Hatsu, M

Kurata, Y

Miyajima, K

Tani, M

Sasaki, T

Kodama, Y

Tsuruoka, T

Omoto, S

机构：

[1] Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Kohoku-ku, Yokohama 222

[2] Department of Biotechnology, Faculty of Agriculture, Gifu University, Gifu 501-11

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 04期

关键词：

D O I：

10.7164/antibiotics.50.309

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of PF1092A (1), B (2) and C (3), new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum, were elucidated by spectroscopic analyses. These compounds possess an eremophilane-type sesquiterpene carbon skeleton and differ only in that 1 and 2 are different monoacetates of 3. The absolute configurations of 1 similar to 3 were determined by single crystal X-ray diffraction analysis of the 4-bromobenzoyl ester of PF1092A and by measuring the optical rotations of the acetylation products of these compounds.

引用

页码：309 / 313

页数：5

共 8 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].