Fruits and Vegetables Consumption and Risk of Stroke A Meta-Analysis of Prospective Cohort Studies

被引:215
作者
Hu, Dan [1 ]
Huang, Junqian [1 ]
Wang, Yuchun [2 ]
Zhang, Dongfeng [3 ]
Qu, Yan [1 ]
机构
[1] Qingdao Municipal Hosp, Intens Care Unit, Qingdao 266071, Peoples R China
[2] Hiser Med Ctr, Intens Care Unit, Qingdao, Peoples R China
[3] Qingdao Univ, Coll Med, Dept Epidemiol & Hlth Stat, Qingdao 266071, Peoples R China
关键词
fruit; meta-analysis; stroke; vegetables; CARDIOVASCULAR-DISEASE MORTALITY; LIFE-STYLE FACTORS; MAJOR DIETARY PATTERNS; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; ISCHEMIC-STROKE; MEDITERRANEAN DIET; INCIDENT STROKE; JAPANESE MEN; MYOCARDIAL-INFARCTION;
D O I
10.1161/STROKEAHA.114.004836
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Background and Purpose-We conducted a meta-analysis to summarize evidence from prospective cohort studies about the association of fruits and vegetables consumption with the risk of stroke. Methods-Pertinent studies were identified by a search of Embase and PubMed databases to January 2014. Study-specific relative risks with 95% confidence intervals were pooled using a random-effects model. Dose-response relationship was assessed by restricted cubic spline. Results-Twenty prospective cohort studies were included, involving 16 981 stroke events among 760 629 participants. The multivariable relative risk (95% confidence intervals) of stroke for the highest versus lowest category of total fruits and vegetables consumption was 0.79 (0.75-0.84), and the effect was 0.77 (0.71-0.84) for fruits consumption and 0.86 (0.79-0.93) for vegetables consumption. Subgroup and meta-regression showed that the inverse association of total fruits and vegetables consumption with the risk of stroke was consistent in subgroup analysis. Citrus fruits, apples/pears, and leafy vegetables might contribute to the protection. The linear dose-response relationship showed that the risk of stroke decreased by 32% (0.68 [0.56-0.82]) and 11% (0.89 [0.81-0.98]) for every 200 g per day increment in fruits consumption (P for nonlinearity=0.77) and vegetables consumption (P for nonlinearity=0.62), respectively. Conclusions-Fruits and vegetables consumption are inversely associated with the risk of stroke.
引用
收藏
页码:1613 / +
页数:29
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