Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects

被引:240
作者
Castilla, Patricia
Echarri, Rocio
Davalos, Alberto
Cerrato, Francisca
Ortega, Henar
Teruel, Jose Luis
Lucas, Milagros Fernandez
Gomez-Coronado, Diego
Ortuno, Joaquin
Lasuncion, Miguel A.
机构
[1] Hosp Ramon & Cajal, Serv Bioquim Invest, E-28034 Madrid, Spain
[2] Hosp Ramon & Cajal, Serv Nefrol, E-28034 Madrid, Spain
[3] CSIC, Inst Fermentac Ind, Madrid, Spain
[4] Univ Alcala de Henares, Alcala De Henares, Spain
关键词
antioxidants; cholesterol; oxidized LDL; inflammation; hemodialysis; cardiovascular disease;
D O I
10.1093/ajcn/84.1.252
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Patients treated with hemodialysis frequently experience cardiovascular complications attributed, among other causes, to dyslipidemia, increased oxidative stress, and inflammation. Objective: The aim of the study was to study the effects of dietary supplementation with concentrated red grape juice (RGJ), a source of polyphenols, on lipoprotein profile, antioxidant capacity, LDL oxidation, and inflammatory biomarkers. Design: Twenty-six patients receiving hemodialysis and 15 healthy subjects were instructed to drink 100 mL RGJ/d for 14 d. Blood was drawn at baseline, twice during RGJ supplementation, and twice during the 6-mo follow-up period. As a control, 12 other randomly recruited hemodialysis patients not receiving RGJ were studied. Lipids, apolipoproteins, oxidized LDL, and antioxidant vitamins were measured in plasma. The bioavailability of RGJ polyphenols was assessed in healthy subjects. Results: The maximum plasma concentration of quercetin was achieved 3 h after RGJ ingestion, which indicates that supplement-derived polyphenols are rapidly absorbed. In both healthy subjects and hemodialysis patients, RGJ consumption increased the antioxidant capacity of plasma without affecting concentrations of uric acid or ascorbic acid; reduced the concentration of oxidized LDL; and increased the concentration of cholesterol-standardized a-tocopherol. RGJ supplementation also caused a significant decrease in LDL-cholesterol and apolipoprotein B-100 concentrations, while increasing the concentrations of HDL cholesterol and apolipoprotein A-I. In a further study in hemodialysis patients, RGJ supplementation for 3 wk significantly reduced plasma monocyte chemoattractant protein 1, an inflammatory biomarker associated with cardiovascular disease risk. Conclusion: Dietary supplementation with concentrated RGJ improves the lipoprotein profile, reduces plasma concentrations of inflammatory biomarkers and oxidized LDL, and may favor a reduction in cardiovascular disease risk.
引用
收藏
页码:252 / 262
页数:11
相关论文
共 69 条
[1]   Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus) [J].
Auger, C ;
Caporiccio, B ;
Landrault, N ;
Teissedre, PL ;
Laurent, C ;
Cros, G ;
Besançon, P ;
Rouanet, JM .
JOURNAL OF NUTRITION, 2002, 132 (06) :1207-1213
[2]  
Badia E, 2004, AM J CLIN NUTR, V80, P225
[3]   Red wine intake prevents nuclear factor-κB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia [J].
Blanco-Colio, LM ;
Valderrama, M ;
Alvarez-Sala, LA ;
Bustos, C ;
Ortego, M ;
Hernández-Presa, MA ;
Cancelas, P ;
Gómez-Gerique, J ;
Millán, J ;
Egido, J .
CIRCULATION, 2000, 102 (09) :1020-1026
[4]   Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial [J].
Boaz, M ;
Smetana, S ;
Weinstein, T ;
Matas, Z ;
Gafter, U ;
Iaina, A ;
Knecht, A ;
Weissgarten, Y ;
Brunner, D ;
Fainaru, M ;
Green, MS .
LANCET, 2000, 356 (9237) :1213-1218
[5]   PREVALENCE OF SERUM-LIPID ABNORMALITIES IN CHRONIC-HEMODIALYSIS [J].
BRUNZELL, JD ;
ALBERS, JJ ;
HAAS, LB ;
GOLDBERG, AP ;
AGADOA, L ;
SHERRARD, DJ .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1977, 26 (08) :903-910
[6]   Green tea upregulates the low-density lipoprotein receptor through the sterol-regulated element binding protein in HepG2 liver cells [J].
Bursill, C ;
Roach, PD ;
Bottema, CDK ;
Pal, S .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (11) :5639-5645
[7]   Olive oil and red wine antioxidant polyphenols inhibit endothelial activation - Antiatherogenic properties of Mediterranean diet phytochemicals [J].
Carluccio, MA ;
Siculella, L ;
Ancora, MA ;
Massaro, M ;
Scoditti, E ;
Storelli, C ;
Visioli, F ;
Distante, A ;
De Caterina, R .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (04) :622-629
[8]   Alteration in plasma antioxidant capacities in chronic renal failure and hemodialysis patients: a possible explanation for the increased cardiovascular risk in these patients [J].
Clermont, G ;
Lecour, S ;
Lahet, JJ ;
Siohan, P ;
Vergely, C ;
Chevet, D ;
Rifle, G ;
Rochette, L .
CARDIOVASCULAR RESEARCH, 2000, 47 (03) :618-623
[9]   Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation [J].
Day, AP ;
Kemp, HJ ;
Bolton, C ;
Hartog, M ;
Stansbie, D .
ANNALS OF NUTRITION AND METABOLISM, 1997, 41 (06) :353-357
[10]   Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats [J].
Del Bas, JM ;
Fernández-Larrea, J ;
Blay, M ;
Ardèvol, A ;
Salvadó, MJ ;
Arola, L ;
Bladé, C .
FASEB JOURNAL, 2005, 19 (01) :479-+