Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma

被引：17

作者：

Bohn, Siv Kjolsrud

Smeland, Sigbjorn

Sakhi, Amrit Kaur

Thoresen, Magne

Russnes, Kjell Magne

Tausjo, Johan

Svilaas, Ame

Svilaas, Tone

Blomhoff, Rune

机构：

[1] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway

[2] Norwegian Radium Hosp, N-0310 Oslo, Norway

[3] Univ Oslo, Rikshosp, Lipid Clin, Dept Med, N-0027 Oslo, Norway

来源：

CANCER LETTERS | 2006年 / 238卷 / 02期

关键词：

oxidative stress; glutathione; head and neck squamous cell carcinoma; thiols; radiotherapy;

D O I：

10.1016/j.canlet.2005.07.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We have studied the role of systemic oxidative stress for survival of patients with head and neck squamous cell carcinomas (HNSCC). Patients with lowest plasma total GSH levels had the lowest 36 months survival. In patients with post-radiotherapy concentrations of plasma total GSH less than median value, about 73% died during the 36 months follow-up compared to about 21% of patients with GSH values above median. Systemic oxidative stress as assessed by low GSH in post-radiotherapy plasma is associated to outcome in HNSCC patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：240 / 247

页数：8

共 52 条

[1]

A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction [J].