Fracture incidence and characterization in patients on osteoporosis treatment: The ICARO study

被引：91

作者：

Adami, Silvano

Isaia, Giancarlo

Luisetto, Giovanni

Minisola, Salvatore

Sinigaglia, Luigi

Gentilella, Raffaella

Agnusdei, Donato

Iori, Nicoletta

Nuti, Ranuccio

机构：

[1] Eli Lilly Italia SpA, I-50019 Florence, Italy

[2] Univ Verona, Valeggio Sul Mincio Hosp, Rheumathol Dept, I-37100 Verona, Italy

[3] Univ Turin, Dept Internal Med, Turin, Italy

[4] Univ Hosp Padova, Dept Endocrinol, Padua, Italy

[5] Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy

[6] Orthoped Inst G Pini, Milan, Italy

[7] Eli Lilly & Co, Siena, Italy

[8] Univ Siena, Le Scotte Hosp, Dept Internal Med, I-53100 Siena, Italy

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

osteoporosis; treatment resistance; fracture risk; treatment compliance; calcium and vitamin D intake;

D O I：

10.1359/JBMR.060715

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

None of the available osteoporosis therapies have been shown to completely abolish the risk of fractures. In clinical practice, the outcome may be even poorer. In 880 patients prescribed with antiresorptives (alendronate, risedronate, and raloxifene) for > 1 year, a fragility fracture was recorded in 8.9 %/year of them. This incidence is considerably higher than that observed in randomized clinical trials, and it was significantly related to poor compliance and lack of supplementation with calcium and vitamin D.

引用

页码：1565 / 1570

页数：6

共 21 条

[1]

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].

Black, DM ;

Cummings, SR ;

Karpf, DB ;

Cauley, JA ;

Thompson, DE ;

Nevitt, MC ;

Bauer, DC ;

Genant, HK ;

Haskell, WL ;

Marcus, R ;

Ott, SM ;

Torner, JC ;

Quandt, SA ;

Reiss, TF ;

Ensrud, KE .

LANCET, 1996, 348 (9041) :1535-1541

[2]

Brzozowska A, 2002, J Nutr Health Aging, V6, P34

[3]

The impact of compliance with osteoporosis therapy on fracture rates in actual practice [J].

Caro, JJ ;

Ishak, KJ ;

Huybrechts, KF ;

Raggio, G ;

Naujoks, C .

OSTEOPOROSIS INTERNATIONAL, 2004, 15 (12) :1003-1008

[4]

Risk of mortality following clinical fractures [J].

Cauley, JA ;

Thompson, DE ;

Ensrud, KC ;

Scott, JC ;

Black, D .

OSTEOPOROSIS INTERNATIONAL, 2000, 11 (07) :556-561

[5]

A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study [J].

Chesnut, CH ;

Silverman, S ;

Andriano, K ;

Genant, H ;

Gimona, A ;

Harris, S ;

Kiel, D ;

LeBoff, M ;

Maricic, M ;

Miller, P ;

Moniz, C ;

Peacock, M ;

Richardson, P ;

Watts, N ;

Baylink, D .

AMERICAN JOURNAL OF MEDICINE, 2000, 109 (04) :267-276

[6]

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs [J].

Cummings, SR ;

Karpf, DB ;

Harris, F ;

Genant, HK ;

Ensrud, K ;

LaCroix, AZ ;

Black, DM .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (04) :281-289

[7]

Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].

Cummings, SR ;

Black, DM ;

Thompson, DE ;

Applegate, WB ;

Barrett-Connor, E ;

Musliner, TA ;

Palermo, L ;

Prineas, R ;

Rubin, SM ;

Scott, JC ;

Vogt, T ;

Wallace, R ;

Yates, AJ ;

LaCroix, AZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082

[8]

Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial [J].

Delmas, PD ;

Genant, HK ;

Crans, GG ;

Stock, JL ;

Wong, M ;

Siris, E ;

Adachi, JD .

BONE, 2003, 33 (04) :522-532

[9]

Ettinger B, 1998, AM J MANAG CARE, V4, P1377

[10]

Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene -: Results from a 3-year randomized clinical trial [J].

Ettinger, B ;

Black, DM ;

Mitlak, BH ;

Knickerbocker, RK ;

Nickelsen, T ;

Genant, HK ;

Christiansen, C ;

Delmas, PD ;

Zanchetta, JR ;

Stakkestad, J ;

Glüer, CC ;

Krueger, K ;

Cohen, FJ ;

Eckert, S ;

Ensrud, KE ;

Avioli, LV ;

Lips, P ;

Cummings, SR .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07) :637-645

← 1 2 3 →