WHAT'S NEXT FOR ALPHAFOLD AND THE AI PROTEIN-FOLDING REVOLUTION

被引：100

作者：

Callaway, Ewen

机构：

来源：

NATURE | 2022年 / 604卷 / 7905期

关键词：

Structural biology; Computational biology and bioinformatics; Biological techniques; Drug discovery; PREDICTION;

D O I：

10.1038/d41586-022-00997-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

DeepMind software that can predict the 3D shape of proteins is already changing biology.

引用

页码：234 / 238

页数：5

共 11 条

[1]

De novo protein design by deep network hallucination [J].

Anishchenko, Ivan ;

Pellock, Samuel J. ;

Chidyausiku, Tamuka M. ;

Ramelot, Theresa A. ;

Ovchinnikov, Sergey ;

Hao, Jingzhou ;

Bafna, Khushboo ;

Norn, Christoffer ;

Kang, Alex ;

Bera, Asim K. ;

DiMaio, Frank ;

Carter, Lauren ;

Chow, Cameron M. ;

Montelione, Gaetano T. ;

Baker, David .

NATURE, 2021, 600 (7889) :547-+

[2]

Accurate prediction of protein structures and interactions using a three-track neural network [J].

Baek, Minkyung ;

DiMaio, Frank ;

Anishchenko, Ivan ;

Dauparas, Justas ;

Ovchinnikov, Sergey ;

Lee, Gyu Rie ;

Wang, Jue ;

Cong, Qian ;

Kinch, Lisa N. ;

Schaeffer, R. Dustin ;

Millan, Claudia ;

Park, Hahnbeom ;

Adams, Carson ;

Glassman, Caleb R. ;

DeGiovanni, Andy ;

Pereira, Jose H. ;

Rodrigues, Andria V. ;

van Dijk, Alberdina A. ;

Ebrecht, Ana C. ;

Opperman, Diederik J. ;

Sagmeister, Theo ;

Buhlheller, Christoph ;

Pavkov-Keller, Tea ;

Rathinaswamy, Manoj K. ;

Dalwadi, Udit ;

Yip, Calvin K. ;

Burke, John E. ;

Garcia, K. Christopher ;

Grishin, Nick V. ;

Adams, Paul D. ;

Read, Randy J. ;

Baker, David .

SCIENCE, 2021, 373 (6557) :871-+

[3]

Improved prediction of protein-protein interactions using AlphaFold2 [J].

Bryant, P. ;

Pozzati, G. ;

Elofsson, A. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[4]

Can AlphaFold2 predict the impact of missense mutations on structure? [J].

Buel, Gwen R. ;

Walters, Kylie J. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2022, 29 (01) :1-2

[5]

Evans R., 2021, PREPRINT BIORXIV, DOI [10.1101/2021, DOI 10.1101/2021]

[6]

Hartmann S., 2022, PREPRINT BIORXIV, DOI [10.1101/2022.01.21.477219, DOI 10.1101/2022.01.21.477219]

[7]

Computed structures of core eukaryotic protein complexes [J].

Humphreys, Ian R. ;

Pei, Jimin ;

Baek, Minkyung ;

Krishnakumar, Aditya ;

Anishchenko, Ivan ;

Ovchinnikov, Sergey ;

Zhang, Jing ;

Ness, Travis J. ;

Banjade, Sudeep ;

Bagde, Saket R. ;

Stancheva, Viktoriya G. ;

Li, Xiao-Han ;

Liu, Kaixian ;

Zheng, Zhi ;

Barrero, Daniel J. ;

Roy, Upasana ;

Kuper, Jochen ;

Fernandez, Israel S. ;

Szakal, Barnabas ;

Branzei, Dana ;

Rizo, Josep ;

Kisker, Caroline ;

Greene, Eric C. ;

Biggins, Sue ;

Keeney, Scott ;

Miller, Elizabeth A. ;

Fromme, J. Christopher ;

Hendrickson, Tamara L. ;

Cong, Qian ;

Baker, David .

SCIENCE, 2021, 374 (6573) :1340-+

[8]

Highly accurate protein structure prediction with AlphaFold [J].

Jumper, John ;

Evans, Richard ;

Pritzel, Alexander ;

Green, Tim ;

Figurnov, Michael ;

Ronneberger, Olaf ;

Tunyasuvunakool, Kathryn ;

Bates, Russ ;

Zidek, Augustin ;

Potapenko, Anna ;

Bridgland, Alex ;

Meyer, Clemens ;

Kohl, Simon A. A. ;

Ballard, Andrew J. ;

Cowie, Andrew ;

Romera-Paredes, Bernardino ;

Nikolov, Stanislav ;

Jain, Rishub ;

Adler, Jonas ;

Back, Trevor ;

Petersen, Stig ;

Reiman, David ;

Clancy, Ellen ;

Zielinski, Michal ;

Steinegger, Martin ;

Pacholska, Michalina ;

Berghammer, Tamas ;

Bodenstein, Sebastian ;

Silver, David ;

Vinyals, Oriol ;

Senior, Andrew W. ;

Kavukcuoglu, Koray ;

Kohli, Pushmeet ;

Hassabis, Demis .

NATURE, 2021, 596 (7873) :583-+

[9]

Molecular architecture of the inner ring scaffold of the human nuclear pore complex [J].

Kosinski, Jan ;

Mosalaganti, Shyamal ;

von Appen, Alexander ;

Teimer, Roman ;

DiGuilio, Amanda L. ;

Wan, William ;

Bui, Khanh Huy ;

Hagen, Wim J. H. ;

Briggs, John A. G. ;

Glavy, Joseph S. ;

Hurt, Ed ;

Beck, Martin .

SCIENCE, 2016, 352 (6283) :363-365

[10]

Mosalaganti S., 2021, PREPRINT BIORXIV, DOI [10.1101/2021, DOI 10.1101/2021.11.16.467908]

← 1 2 →