Hippocampal volume asymmetry and age at illness onset in males with schizophrenia

被引：33

作者：

Fukuzako, H ^{[1
]}

Yamada, K ^{[1
]}

Kodama, S ^{[1
]}

Yonezawa, T ^{[1
]}

Fukuzako, T ^{[1
]}

Takenouchi, K ^{[1
]}

Kajiya, Y ^{[1
]}

Nakajo, M ^{[1
]}

Takigawa, M ^{[1
]}

机构：

[1] KAGOSHIMA UNIV,FAC MED,DEPT RADIOL,KAGOSHIMA,JAPAN

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 1997年 / 247卷 / 05期

关键词：

hippocampal formation; asymmetry; magnetic resonance imaging; onset; schizophrenia;

D O I：

10.1007/BF02900302

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine whether there are disturbances of hippocampal volume asymmetry in schizophrenic patients, we obtained contiguous, l-mm-thick magnetic resonance images in 28 males with chronic schizophrenia and in 28 age-matched healthy males. The schizophrenic patients showed a bilateral reduction in volume of the hippocampal formation (HF; left 7.0%; right 8.7%). This reduction was significantly associated with the severity of disorganization syndrome (P < 0.0005). A significant asymmetry in the HF volume was found in the control subjects (P = 0.006), but not in the patients (P = 0.40). There was a significant positive correlation between the asymmetry index and the patient's age at the onset of schizophrenia (r = 0.46, P = 0.01). Results indicate that a disturbance in the normal asymmetry of the HF may be a characteristic in schizophrenia, particularly in patients with an early onset of the illness.

引用

页码：248 / 251

页数：4

共 28 条

[1] VALUE OF MAGNETIC-RESONANCE-IMAGING - BASED MEASUREMENTS OF HIPPOCAMPAL FORMATIONS IN PATIENTS WITH PARTIAL EPILEPSY [J].