Electrophilic cyanations .1. Synthesis of thiocyanatoheteroarenes and tosylheteroarenes from mercaptoheteroarenes using p-toluenesulfonyl cyanide

被引：19

作者：

Miyashita, A

Nagasaki, I

Kawano, A

Suzuki, Y

Iwamoto, K

Higashino, T

机构：

[1] School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422

来源：

HETEROCYCLES | 1997年 / 45卷 / 04期

关键词：

D O I：

10.3987/COM-97-7740

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mercaptoheteroarenes (1) underwent electrophilic cyanation with p-toluenesulfonyl cyanide (TsCN) in THF in the presence of NaH to give the corresponding thiocyanatoheteroarenes (2) in moderate to good yields. In DMF, tosylheteroarenes (4) were formed by substitution with p-toluenesulfinate ion through thiocyanatoheteroarenes (2).

引用

页码：745 / 755

页数：11

共 29 条

[1] IONIZATION CONSTANTS OF HETEROCYCLIC SUBSTANCES .3. MERCAPTO-DERIVATIVES OF PYRIDINE, QUINOLINE, AND ISOQUINOLINE [J].