Preparation of NiFe2O4/graphene nanocomposite and its application as a modifier for the fabrication of an electrochemical sensor for the simultaneous determination of tramadol and acetaminophen

被引：143

作者：

Afkhami, Abbas ^{[1
]}

Khoshsafar, Hosein ^{[1
]}

Bagheri, Hasan ^{[2
]}

Madrakian, Tayyebeh ^{[1
]}

机构：

[1] Bu Ali Sina Univ, Fac Chem, Hamadan, Iran

[2] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran

来源：

ANALYTICA CHIMICA ACTA | 2014年 / 831卷

关键词：

Electrochemical sensor; Chemically modified carbon paste electrode; Magnetic nanoparticles; Graphene; Simultaneous determination of tramadol and acetaminophen; CARBON-PASTE ELECTRODE; SIMULTANEOUS VOLTAMMETRIC DETERMINATION; NIFE2O4 MAGNETIC NANOPARTICLES; MOLECULARLY IMPRINTED POLYMER; IONIC LIQUID; SENSITIVE DETERMINATION; GRAPHENE OXIDE; GOLD NANOPARTICLES; ASCORBIC-ACID; SENSING PLATFORM;

D O I：

10.1016/j.aca.2014.04.061

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

An effective electrochemical sensor for the rapid and simultaneous determination of tramadol and acetaminophen based on carbon paste electrode (CPE) modified with NiFe2O4/graphene nanoparticles was developed. The structures of the synthesized NiFe2O4/graphene nanocomposite and the electrode composition were confirmed by X-ray diffraction (XRD) spectrometry, Fourier transform infrared (FT-IR) spectrometry and scanning electron microscopy (SEM). The peak currents of square wave voltammetry of tramadol and acetaminophen increased linearly with their concentration in the range of 0.01-9 mu mol L (1). The detection limit for their determination was found to be 0.0036 and 0.0030 mu mol L (1), respectively. The results show that the combination of graphene and NiFe2O4 nanoparticles causes a dramatic enhancement in the sensitivity of the sensor. The fabricated sensor exhibited high sensitivity and good stability, and would be valuable for the clinical assay of tramadol and acetaminophen. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：50 / 59

页数：10

共 41 条

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Surface decoration of multi-walled carbon nanotubes modified carbon paste electrode with gold nanoparticles for electro-oxidation and sensitive determination of nitrite [J].