Gut microbiota, enteroendocrine functions and metabolism

被引：348

作者：

Cani, Patrice D. ^{[1
]}

Everard, Amandine ^{[1
]}

Duparc, Thibaut ^{[1
]}

机构：

[1] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & BIOtechnol, Metab & Nutr Res Grp, B-1200 Brussels, Belgium

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 06期

关键词：

FATTY-ACID RECEPTOR; PROTEIN-COUPLED RECEPTORS; AKKERMANSIA-MUCINIPHILA; PEPTIDE-1; SECRETION; OBESE MICE; DIET; GLUCOSE; ENDOTOXEMIA; INCREASES; GPR119;

D O I：

10.1016/j.coph.2013.09.008

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The gut microbiota affects host metabolism through a number of physiological processes. Emerging evidence suggests that gut microbes interact with the host through several pathways involving enteroendocrine cells (e.g. L cells). The activation of specific G protein coupled receptors expressed on L cells (e.g. GPR41, GPR43, GPR119 and TGR5) triggers the secretion of glucagon-like peptides (GLP-1 and GLP-2) and PYY. These gut peptides are known to control energy homeostasis, glucose metabolism, gut barrier function and metabolic inflammation. Here, we explore how crosstalk between the ligands produced by the gut microbiota (short chain fatty acids, or SCFAs), or produced by the host but influenced by gut microbes (endocannabinoids and bile acids), impact host physiology.

引用

页码：935 / 940

页数：6

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