Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats

被引：76

作者：

Yu, Hai-Yang ^{[1
]}

Yin, Zhu-Jun ^{[1
]}

Yang, Shui-Jin ^{[1
]}

Ma, Shi-Ping ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 10009, Jiangsu, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 451卷 / 04期

关键词：

Baicalin; GluR2; subunit; Bax; Bc1-2; Caspase-3; Antidepressant; MAJOR DEPRESSIVE DISORDER; SYNAPTIC PLASTICITY; CORTICAL-NEURONS; MOLECULAR NEUROBIOLOGY; NEUROTROPHIC FACTOR; CYTOCHROME-C; MODEL; BRAIN; ANTIDEPRESSANT; HIPPOCAMPUS;

D O I：

10.1016/j.bbrc.2014.07.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Changes of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression could impacts the viability of neurons and brain levels of brain-derived neurotrophic factor (BDNF) expression in the key brain structures in the pathophysiology of depressive disorder. In the present study, chronic unpredictable mild stress (CUMS) degraded performance decreased AMPA receptor expression and increased neuron apoptosis. Treatment with baicalin (20, 40 mg/kg) significantly reversed these changes. This study demonstrates that baicalin has potent antidepressant effect, likely through up-regulated the expression of AMPA receptor and suppression neuron apoptosis in CUMS-treated rats. (C) 2014 Published by Elsevier Inc.

引用

收藏

页码：467 / 472

页数：6

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