Synthesis and erosion studies of self-catalyzed poly(ortho ester)s

被引：53

作者：

Ng, SY ^{[1
]}

Vandamme, T ^{[1
]}

Taylor, MS ^{[1
]}

Heller, J ^{[1
]}

机构：

[1] ADV POLYMER SYST RES INST,REDWOOD CITY,CA 94063

来源：

MACROMOLECULES | 1997年 / 30卷 / 04期

关键词：

D O I：

10.1021/ma9610626

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new variation of poly(ortho ester)s prepared by the addition of diols to the diketene acetal 3,9-diethylidene-2,4,8,10-tetraoxaspiro[5.5]undecane is described. In this variation, a short segment of a glycolic acid dimer is built into the polymer backbone. Such a material does not require the addition of acidic excipients to control polymer hydrolysis rate, as was necessary in previous systems, and excellent control over erosion rate without attendant problems of loss of excipient by diffusion has been achieved.

引用

页码：770 / 772

页数：3

共 11 条

[1]

HELLER J, 1987, Journal of Controlled Release, V6, P217, DOI 10.1016/0168-3659(87)90078-2

[2] PREPARATION OF POLY(ORTHO ESTERS) BY THE REACTION OF DIKETENE ACETALS AND POLYOLS [J].