The importance of manganese superoxide dismutase in delayed preconditioning: Involvement of reactive oxygen species and cytokines

被引：67

作者：

Hoshida, S ^{[1
]}

Yamashita, N

Otsu, K

Hori, M

机构：

[1] Osaka Univ, Dept Internal Med & Therapeut, Suita, Osaka 5918025, Japan

[2] Osaka Rosai Hosp, Div Cardiol, Sakai, Osaka, Japan

来源：

CARDIOVASCULAR RESEARCH | 2002年 / 55卷 / 03期

关键词：

cytokines; ischemia; preconditioning;

D O I：

10.1016/S0008-6363(02)00337-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is clinically important to elucidate the mechanism underlying the delayed preconditioning against ischomia-reperfusion injury observed 24-72 It after sublethal stress such as brief ischemia, hyperthermia and exercise. The time course of induction of myocardial manganese-superoxide dismutase (Mn-SOD) and appearance of the ischemic tolerance coincide and the percent increase in Mn-SOD activity and percent reduction of infarct size are correlated well under various stresses. Furthermore, treatments with antisense oligodeoxynucleotides to Mn-SOD completely abolished the delayed preconditioning and any increase in Mn-SOD content. These results indicate that Mn-SOD induction plays a pivotal role in the late phase preconditioning afforded with brief ischemia, hyperthermia and exercise. we also showed that cytokines, e.g., tumor necrosis factor-alpha and interleukin- 1 beta, and reactive oxygen species are involved in the process of signal transduction for the Mn-SOD induction. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：495 / 505

页数：11

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