Prospective function of placental leptin at maternal-fetal interface

被引：90

作者：

Bajoria, R

Sooranna, SR

Ward, BS

Chatterjee, R

机构：

[1] Univ Manchester, St Marys Hosp, Acad Unit Obstet & Gynaecol, Manchester M13 0JH, Lancs, England

[2] UCL Hosp, Dept Reprod Med, London, England

[3] Chelsea & Westminster Hosp, Dept Mat & Fetal Med, London, England

来源：

PLACENTA | 2002年 / 23卷 / 2-3期

关键词：

D O I：

10.1053/plac.2001.0769

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leptin is an endocrine and a growth factor which is important for regulation of body fat, feeding, and energy homeostasis. The anti-obesity function of leptin has been recently extended to reproduction, puberty and pregnancy as an endocrine signal to the hypothalamus. Leptin controls the functional integrity of the feto-placental unit thereby maintaining pregnancy by virtue of its immunomodulatory property via T lymphocytes or other proto-oncogenes. Dysregulation of autocrine/paracrine function of leptin at feto-placento-maternal interface may be implicated in the pathogenesis of recurrent miscarriage gestational diabetes, pre-eclampsia and intra-uterine fetal growth retardation including disturbance of fetal bone turnover. This review will focus on the role of leptin in normal and abnormal pregnancy and fetal growth. (C) 2002 Elsevier Science Ltd.

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页码：103 / 115

页数：13

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