Translating Glycolytic Metabolism to Innate Immunity in Dendritic Cells

被引：30

作者：

Cortese, Mario ^{[1
]}

Sinclair, Charles ^{[1
]}

Pulendran, Bali ^{[1
]}

机构：

[1] Emory Vaccine Ctr, Atlanta, GA 30329 USA

来源：

CELL METABOLISM | 2014年 / 19卷 / 05期

关键词：

ACTIVATION;

D O I：

10.1016/j.cmet.2014.04.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Growing evidence supports a role for glycolysis in immune activation. Everts et al. (2014) now show that TLR-mediated stimulation of dendritic cells rapidly induces glycolysis, which regenerates NADPH and TCA intermediates to support fatty acid production. This enhances ER and Golgi membrane synthesis and innate activation of dendritic cells.

引用

页码：737 / 739

页数：3

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