Non-genomic effects of progesterone on the signaling function of G protein-coupled receptors

被引：54

作者：

Burger, K ^{[1
]}

Fahrenholz, F ^{[1
]}

Gimpl, G ^{[1
]}

机构：

[1] Univ Mainz, Inst Biochem, D-55099 Mainz, Germany

来源：

FEBS LETTERS | 1999年 / 464卷 / 1-2期

关键词：

progesterone; non-genomic effect; G protein-coupled receptor; calcium signal; anisotropy;

D O I：

10.1016/S0014-5793(99)01668-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Progesterone at concentrations between 10 mu M and 200 mu M affected the calcium signaling evoked by ligand stimulation of G protein-coupled receptors expressed in several cell lines. At 160 mu M progesterone the signaling of all receptors,vas completely abolished. The effect of progesterone was fast, reversible and was not prevented by cycloheximide indicating its non-genomic nature. Overall, the action of progesterone was more cell type-specific than receptor-specific. Our results are in contrast to a recent report [Grazzini, E., Guillon, G., Mouillac, B. and Zingg, H.H. (1998) Nature 392, 509-512] in which a direct high-affinity interaction between the oxytocin receptor and progesterone was suggested. (C) 1999 Federation of European Biochemical Societies.

引用

页码：25 / 29

页数：5

共 22 条

[1] Nongenomic progesterone receptor on human spermatozoa: biochemical aspects and clinical implications [J].