Antiviral immunity in drosophila

被引：112

作者：

Kemp, Cordula ^{[1
]}

Imler, Jean-Luc ^{[1
,2
]}

机构：

[1] CNRS, UPR9022, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

[2] Univ Strasbourg, Fac Sci Vie, F-67070 Strasbourg, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 01期

关键词：

DOUBLE-STRANDED-RNA; DISTINCT ROLES; HOST-DEFENSE; VIRUS; INDUCTION; PATHWAY; MELANOGASTER; SUPPRESSION; MECHANISM; INFECTION;

D O I：

10.1016/j.coi.2009.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.

引用

页码：3 / 9

页数：7

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