Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone

被引：107

作者：

Nagano, T

Yoneda, T

Hatanaka, Y

Kubota, C

Murakami, F

Sato, M

机构：

[1] Fukui Med Univ, Dept Anat 2, Fukui 9101193, Japan

[2] Osaka City Univ, Sch Med, Dept Anat 1, Abeno Ku, Osaka 5458585, Japan

[3] Natl Inst Basic Biol, Div Behav Neurobiol, Aichi 4448585, Japan

[4] Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

[5] Osaka Univ, Grad Sch Frontier Biosci, Neurosci Lab, Osaka 5608531, Japan

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 07期

关键词：

D O I：

10.1038/ncb808

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Precisely regulated radial migration out of the ventricular zone is essential for corticogenesis. Here, we identify a mechanism that can tether ventricular zone cells in situ. FILIP interacts with Filamin A, an indispensable actin-binding protein that is required for cell motility, and induces its degradation in COS-7 cells. Degradation of Filamin A is identified in the cortical ventricular zone, where filip mRNA is localized. Furthermore, most ventricular zone cells that overexpress FILIP fail to migrate in explants. These results demonstrate that FILIP functions through a Filamin A-F-actin axis to control the start of neocortical cell migration from the ventricular zone.

引用

页码：495 / 501

页数：7

共 31 条

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