Corticatic acids D and E, polyacetylenic geranylgeranyltransferase type I inhibitors, from the marine sponge Petrosia corticata

被引：28

作者：

Nishimura, S

Matsunaga, S

Shibazaki, M

Suzuki, K

Harada, N

Naoki, H

Fusetani, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] Yamanouchi Pharmaceut Co Ltd, Drug Serendip Res Labs, Dept Microbiol Res, Itabashi Ku, Tokyo 1748511, Japan

[3] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan

[4] Suntory Inst Bioorgan Res, Osaka 6180024, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1021/np020080f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new polyacetylenic acids, corticatic acids D (2) and E (3), have been isolated from the marine sponge Petrosia corticata along with the known corticatic acid A (1) as geranylgeranyltransferase type I (GGTase I) inhibitors. Their structures were elucidated on the basis of spectroscopic and chemical methods. Compounds 1-3 inhibited GGTase I from Candida albicans with IC50 values of 1.9-7.3 muM.

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页码：1353 / 1356

页数：4

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