Blood Circulation and Tissue Biodistribution of Lipid-Quantum Dot (L-QD) Hybrid Vesicles Intravenously Administered in Mice

被引：43

作者：

Al-Jamal, Wafa T. ^{[1
]}

Al-Jamal, Khuloud T. ^{[1
]}

Cakebread, Andrew ^{[2
]}

Halket, John M. ^{[2
]}

Kostarelos, Kostas ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England

[2] Kings Coll London, Dept Forens Sci & Drug Monitoring, London SE1 9NH, England

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 09期

关键词：

IN-VIVO; CATIONIC LIPOSOMES; TUMOR VASCULATURE; GENE DELIVERY; SERUM; STABILITY; COMPLEXES; PHARMACOKINETICS; DOXORUBICIN; EXPRESSION;

D O I：

10.1021/bc900047n

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present work describes the pharmacokinctics of recently developed liposome-quantum dot (L-QD) hybrid vesicles in nude mice following systemic administration. Hydrophobic QD were incorporated into different bilayer compositions, and the serum stability of such hybrid vesicles was evaluated using turbidity and carboxyfluorescein release measurements. L-QD hybrid blood profile and organ biodistribution were also determined by elemental (cadmium) analysis. Following intravenous administration, different tissue biodistribution profiles and tissue affinities were observed depending on the L-QD lipid bilayer characteristics. Immediate blood clearance was observed with cationic (DOTAP/DOPE/Chol) hybrid with rapid lung accumulation, while incorporation of PEG at the surface of zwitterionic vesicles dramatically prolonged their blood circulation half-life after systemic administration. Overall, the L-QD hybrid vesicle system is considered a viable platform that allows QD delivery to different tissues through facile modulation of the hybrid vesicle characteristics. In addition, L-QD offers many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle.

引用

页码：1696 / 1702

页数：7

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