Analysis of Genes, Transcripts, and Proteins via DNA Ligation

被引：34

作者：

Conze, Tim ^{[1
]}

Shetye, Alysha ^{[1
]}

Tanaka, Yuki ^{[1
]}

Gu, Jijuan ^{[1
]}

Larsson, Chatarina ^{[1
]}

Goeransson, Jenny ^{[1
]}

Tavoosidana, Gholamreza ^{[1
]}

Soederberg, Ola ^{[1
]}

Nilsson, Mats ^{[1
]}

Landegren, Ulf ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, Uppsala, Sweden

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY | 2009年 / 2卷

关键词：

proximity ligation assay; padlock probes; SNP genotyping; interaction analysis; in situ protein analysis; ROLLING-CIRCLE AMPLIFICATION; IN-SITU DETECTION; SINGLE-MOLECULE DETECTION; NUCLEIC-ACID SEQUENCES; LIGASE CHAIN-REACTION; PADLOCK PROBES; PROXIMITY LIGATION; POINT MUTATIONS; MULTIPLEX AMPLIFICATION; OLIGONUCLEOTIDE LIGATION;

D O I：

10.1146/annurev-anchem-060908-155239

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Analytical reactions in which short DNA strands are used in combination with DNA ligases have proven useful for measuring, decoding, and locating most classes of macromolecules. Given the need to accumulate large amounts of precise molecular information from biological systems in research and ill diagnostics, ligation reactions will continue to offer valuable strategies for advanced analytical reactions. Here, we provide a basis for further development of methods by reviewing the history of analytical ligation reactions, discussing the properties of ligation reactions that render them suitable for engineering novel assays, describing a wide range of successful ligase-based assays, and briefly considering future directions.

引用

页码：215 / 239

页数：25

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