Calpain-related diseases

被引：47

作者：

Branca, D

机构：

[1] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

[2] Venetian Inst Mol Med, I-35121 Padua, Italy

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 322卷 / 04期

关键词：

D O I：

10.1016/j.bbrc.2004.07.126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calpains are calcium-modulated proteases which respond to Ca2+ signals by removing limited portions of protein substrates, thereby irreversibly modifying their function(s). Members of this protease family are present in a variety of organisms ranging from mammals to plants; some of them are ubiquitously expressed, while others are tissue specific. Although calpains are apparently involved in a multitude of physiological and pathological events, their functions are still poorly understood. In two cases, however, the alteration of a member of the calpain family has been clearly identified as being responsible for a human disease: the loss of function of calpain 3 causes limb girdle muscular dystrophy type 2A, and mutations in the gene coding for calpain 10 have been shown to correlate with non-insulin-dependent diabetes. (C) 2004 Elsevier Inc. All rights reserved.

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页码：1098 / 1104

页数：7

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