Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development

被引：85

作者：

Ikegami, Kohta

Ohgane, Jun

Tanaka, Satoshi

Yagi, Shintaro

Shiota, Kunio ^{[1
,2
]}

机构：

[1] Univ Tokyo, Lab Cellular Biochem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan

[2] Natl Inst Adv Ind Sci & Technol, Organ Dev Res Lab, Tsukuba, Ibaraki, Japan

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2009年 / 53卷 / 2-3期

基金：

日本学术振兴会;

关键词：

epigenetics; DNA methylation; T-DMR; histone modification; chromatin remodeling; CPG-BINDING-PROTEIN; DE-NOVO METHYLATION; EMBRYONIC STEM; GENOME-WIDE; METHYLTRANSFERASE G9A; EPIGENETIC REGULATION; H3; METHYLATION; LYSINE-9; CYTOSINE METHYLATION; GENE-EXPRESSION;

D O I：

10.1387/ijdb.082741ki

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genes constitute only a small proportion of the mammalian genome, the majority of which is composed of non-genic repetitive elements including interspersed repeats and satellites. A unique feature of the mammalian genome is that there are numerous tissue-dependent, differentially methylated regions (T-DMRs) in the non-repetitive sequences, which include genes and their regulatory elements. The epigenetic status of T-DMRs varies from that of repetitive elements and constitutes the DNA methylation profile genome-wide. Since the DNA methylation profile is specific to each cell and tissue type, much like a fingerprint, it can be used as a means of identification. The formation of DNA methylation profiles is the basis for cell differentiation and development in mammals. The epigenetic status of each T-DMR is regulated by the interplay between DNA methyltransferases, histone modification enzymes, histone subtypes, non-histone nuclear proteins and non-coding RNAs. In this review, we will discuss how these epigenetic factors cooperate to establish cell- and tissue-specific DNA methylation profiles.

引用

页码：203 / 214

页数：12

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