Mechanisms for cellular cholesterol transport: Defects and human disease

被引：175

作者：

Ikonen, Elina ^{[1
]}

机构：

[1] Univ Helsinki, Inst Biomed Anat, FIN-00014 Helsinki, Finland

来源：

PHYSIOLOGICAL REVIEWS | 2006年 / 86卷 / 04期

关键词：

D O I：

10.1152/physrev.00022.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This review summarizes the mechanisms of cellular cholesterol transport and monogenic human diseases caused by defects in intracellular cholesterol processing. In addition, selected mouse models of disturbed cholesterol trafficking are discussed. Current pharmacological strategies to prevent atherosclerosis are largely based on altering cellular cholesterol balance and are introduced in this context. Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.

引用

页码：1237 / 1261

页数：25

共 278 条

[1] Neuronal membrane cholesterol loss enhances amyloid pepticle generation [J].

Abad-Rodriguez, J ;

Ledesma, MD ;

Craessaerts, K ;

Perga, S ;

Medina, M ;

Delacourte, A ;

Dingwall, C ;

De Strooper, B ;

Dotti, CG .

JOURNAL OF CELL BIOLOGY, 2004, 167 (05) :953-960

[2] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].

Abifadel, M ;

Varret, M ;

Rabès, JP ;

Allard, D ;

Ouguerram, K ;

Devillers, M ;

Cruaud, C ;

Benjannet, S ;

Wickham, L ;

Erlich, D ;

Derré, A ;

Villéger, L ;

Farnier, M ;

Beucler, I ;

Bruckert, E ;

Chambaz, J ;

Chanu, B ;

Lecerf, JM ;

Luc, G ;

Moulin, P ;

Weissenbach, J ;

Prat, A ;

Krempf, M ;

Junien, C ;

Seidah, NG ;

Boileau, C .

NATURE GENETICS, 2003, 34 (02) :154-156

[3]

ABILDAYEVA K, IN PRESS J BIOL CHEM

[4] ABCA1-deficient mice - Insights into the role of monocyte lipid efflux in HDL formation and inflammation [J].

Aiello, RJ ;

Brees, D ;

Francone, OL .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (06) :972-980

[5] Give lipids a START: The StAR-related lipid transfer (START) domain in mammals [J].

Alpy, F ;

Tomasetto, C .

JOURNAL OF CELL SCIENCE, 2005, 118 (13) :2791-2801

[6] Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption [J].

Altmann, SW ;

Davis, HR ;

Zhu, LJ ;

Yao, XR ;

Hoos, LM ;

Tetzloff, G ;

Iyer, SPN ;

Maguire, M ;

Golovko, A ;

Zeng, M ;

Wang, LQ ;

Murgolo, N ;

Graziano, MP .

SCIENCE, 2004, 303 (5661) :1201-1204

[7] MUTATIONS AT THE LYSOSOMAL ACID CHOLESTERYL ESTER HYDROLASE GENE LOCUS IN WOLMAN-DISEASE [J].

ANDERSON, RA ;

BYRUM, RS ;

COATES, PM ;

SANDO, GN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) :2718-2722

[8]

[Anonymous], 1995, FAMILIAL HYPERCHOLES

[9] Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH:: a clinical and molecular genetic analysis [J].

Arca, M ;

Zuliani, G ;

Wilund, K ;

Campagna, F ;

Fellin, R ;

Bertolini, S ;

Calandra, S ;

Ricci, G ;

Glorioso, N ;

Maioli, M ;

Pintus, P ;

Carru, C ;

Cossu, F ;

Cohen, J ;

Hobbs, HH .

LANCET, 2002, 359 (9309) :841-847

[10] The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly [J].

Aridor, M ;

Fish, KN ;

Bannykh, S ;

Weissman, J ;

Roberts, TH ;

Lippincott-Schwartz, J ;

Balch, WE .

JOURNAL OF CELL BIOLOGY, 2001, 152 (01) :213-229

← 1 2 3 4 5 6 7 8 9 10 →