GC/MS determination of zolpidem in postmortem specimens in a voluntary intoxication

被引：29

作者：

Keller, T ^{[1
]}

Schneider, A ^{[1
]}

Tutsch-Bauer, E ^{[1
]}

机构：

[1] Paris Lodron Univ, Inst Forens Med, A-5020 Salzburg, Austria

来源：

FORENSIC SCIENCE INTERNATIONAL | 1999年 / 106卷 / 02期

关键词：

toxicology; drug abuse; Ivadal (R); zolpidem; overdose; GC/MS;

D O I：

10.1016/S0379-0738(99)00185-1

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

An ingestion of an unknown quantity of Ivadal(R) (zolpidem) tablets in a case of drug abuse is described, The authors report a new and fast method of analysing and determining the zolpidem concentration in postmortem specimens, Quantitation of zolpidem was performed by ethyl acetate extraction from alkalinized body fluids before GC/MS analysis. The analyses were performed without any complex sample clean-up steps and with little sample material. Postmortem concentrations of zolpidem in body fluids are given. The proposed method is a rapid procedure of analysis in cases of deliberate poisoning with the sedative-hypnotic drug, zolpidem. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：103 / 108

页数：6

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