Potential Uses of Hemoglobin-based Oxygen Carriers in Critical Care Medicine

被引：17

作者：

Creteur, Jacques ^{[1
]}

Vincent, Jean-Louis ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Erasme Hosp, Dept Intens Care, B-1070 Brussels, Belgium

来源：

CRITICAL CARE CLINICS | 2009年 / 25卷 / 02期

关键词：

Oncotic pressure; Nitric oxide; Sepsis; Perioperative blood loss; Transfusion; Oxygen transport; Red blood cell; Trauma; CROSS-LINKED HEMOGLOBIN; POLYMERIZED BOVINE HEMOGLOBIN; LIPOSOME-ENCAPSULATED HEMOGLOBIN; FOCAL CEREBRAL-ISCHEMIA; FACTOR-ALPHA PRODUCTION; NITRIC-OXIDE; HEMORRHAGIC-SHOCK; BLOOD SUBSTITUTES; SYSTEMIC HEMODYNAMICS; EXCHANGE-TRANSFUSION;

D O I：

10.1016/j.ccc.2008.12.011

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Hemoglobin-based oxygen carriers (HBOCs) were initially developed to provide an alternative to blood transfusion. With the realization that hemoglobin solutions not only are red blood cell substitutes but also have a number of additional properties, including hemodynamic effects related to their oncotic and nitric oxide-scavenging effects, the broader concept of "hemoglobin therapeutics" was born. Promising effects on oxygen transport and the microcirculation need to be confirmed, and the results of studies with newer, second-generation HBOCs are eagerly awaited. In the meantime, possible adverse effects need to be carefully evaluated before HBOCs can be widely used in the ICU, emergency room, or prehospital setting.

引用

页码：311 / +

页数：15

共 92 条

[1] Effect of human hemoglobin on systemic and regional hemodynamics in a porcine model of endotoxemic shock [J].

Aranow, JS ;

Wang, HL ;

Zhuang, J ;

Fink, MP .

CRITICAL CARE MEDICINE, 1996, 24 (05) :807-814

[2] A prospective trial of diaspirin cross-linked hemoglobin solution in patients after elective repair of abdominal aortic aneurysm [J].

Bloomfield, EL ;

Rady, MY ;

Esfandiari, S .

MILITARY MEDICINE, 2004, 169 (07) :546-550

[3] Comparison of the haemodynamic effects of nitric oxide synthase inhibition and nitric oxide scavenging in endotoxaemic sheep [J].

Bone, HG ;

Waurick, R ;

Van Aken, H ;

Booke, M ;

Prien, T ;

Meyer, J .

INTENSIVE CARE MEDICINE, 1998, 24 (01) :48-54

[4] Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep [J].

Bone, HG ;

Schenarts, PJ ;

Booke, M ;

McGuire, R ;

Harper, D ;

Traber, LD ;

Traber, DL .

CRITICAL CARE MEDICINE, 1997, 25 (06) :1010-1018

[5] Diffusion coefficients of oxygen and hemoglobin measured by facilitated oxygen diffusion through hemoglobin solutions [J].

Bouwer, ST ;

Hoofd, L ;

Kreuzer, F .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1997, 1338 (01) :127-136

[6] DIASPIRIN CROSS-LINKED HEMOGLOBIN IMPROVES NEUROLOGICAL OUTCOME FOLLOWING REVERSIBLE BUT NOT IRREVERSIBLE CNS ISCHEMIA IN RABBITS [J].

BOWES, MP ;

BURHOP, KE ;

ZIVIN, JA .

STROKE, 1994, 25 (11) :2253-2257

[7] Effects of prophylactic or therapeutic application of bovine haemoglobin HBOC-200 on ischaemia-reperfusion injury following acute coronary ligature in rats [J].

Burmeister, MA ;

Rempf, C ;

Standl, TG ;

Bartsch-Zwemke, S ;

Krause, T ;

Tuszynski, S ;

Gottschalk, A ;

Schulte am Esch, J .

BRITISH JOURNAL OF ANAESTHESIA, 2005, 95 (06) :737-745

[8] Free hemoglobin enhances tumor necrosis factor-α production in isolated human monocytes [J].

Carrillo, EH ;

Gordon, LE ;

Richardson, JD ;

Polk, HC .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2002, 52 (03) :449-452

[9] A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury [J].

Caswell, JE ;

Strange, MB ;

Rimmer, DM ;

Gibson, MF ;

Cole, P ;

Lefer, DJ .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2005, 288 (04) :H1796-H1801

[10] Diaspirin cross-linked hemoglobin resuscitation improves cerebral perfusion after head injury and shock [J].

Chappell, JE ;

McBride, WJ ;

Shackford, SR .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1996, 41 (05) :781-788

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