Formation of 2-substituted iodobenzenes from iodobenzene via benzyne and ate complex intermediates

被引：42

作者：

Tripathy, S ^{[1
]}

LeBlanc, R ^{[1
]}

Durst, T ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 12期

关键词：

D O I：

10.1021/ol991129k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The generation of benzyne from iodobenzene with lithium tetramethylpiperidide in THF at -40 degrees C in the presence of lithium amides and ester enolates leads to mixtures in which 2-substituted iodobenzenes are often the major products, These products are obtained by iodine transfer from iodobenzene to the intermediate 2-lithioaromatics. The transfer of iodine occurs via a hypervalent iodine (ate) complex.

引用

页码：1973 / 1975

页数：3

共 5 条

[1] A RAPID, CONVERGENT, AND REGIOSELECTIVE SYNTHESIS OF ANTHRACENES [J].