Cancer immunotherapy: moving beyond current vaccines

被引：2448

作者：

Rosenberg, SA ^{[1
]}

Yang, JC ^{[1
]}

Restifo, NP ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, Surg Branch, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1038/nm1100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on surrogate endpoints than on clinical tumor regression. In our cancer vaccine trials of 440 patients, the objective response rate was low (2.6%), and comparable to the results obtained by others. We consider here results in cancer vaccine trials and highlight alternate strategies that mediate cancer regression in preclinical and clinical models.

引用

页码：909 / 915

页数：7

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