Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation

被引：31

作者：

Haining, WN

Evans, JW

Seth, NP

Callaway, GD

Wucherpfennig, KW

Nadler, LM

Guinan, EC

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[4] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2004年 / 127卷 / 03期

关键词：

malignant lymphomas; molecular pathogenesis; immunodeficiency; somatic mutation; proto-oncogenes;

D O I：

10.1111/j.1365-2141.2004.05204.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Quantitative assessment of immunogen-specific T cell responses may provide a meaningful surrogate marker of functional immunity in patients following haemopoietic stem cell transplantation (HSCT). We developed a flow-cytometric assay to quantify antigen-specific T cell immunity to influenza-A and studied the T cell response to influenza vaccination in five children, 3 21 months post-HSCT. All patients showed an increase in influenza-A-specific CD4(+) immunity following vaccination while none had a detectable IgG response to the vaccine. This assay proved sufficiently sensitive to evaluate changes in T cell memory in immunocompromised individuals and could be used to better characterize post-HSCT immune reconstitution.

引用

收藏

页码：322 / 325

页数：4

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