Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol

被引：111

作者：

Calderon, Marcelo ^{[2
]}

Graeser, Ralph ^{[3
]}

Kratz, Felix ^{[1
]}

Haag, Rainer ^{[2
]}

机构：

[1] Tumor Biol Ctr, D-79106 Freiburg, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[3] Proquinase, D-79106 Freiburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 14期

关键词：

Polyglycerol; Polymer therapeutics; Prodrug; Doxorubicin; Methotrexate; Drug conjugate; Controlled release; Nanocarrier; DESIGNING DENDRIMERS; DRUG-DELIVERY; THERAPEUTICS; METHOTREXATE; ALBUMIN;

D O I：

10.1016/j.bmcl.2009.05.058

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3725 / 3728

页数：4

共 30 条

[1]

In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B [J].

Abu Ajaj, Khalid ;

Graeser, Ralph ;

Fichtner, Iduna ;

Kratz, Felix .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 64 (02) :413-418

[2]

Glycerol and glycerol glycol glycodendrimers [J].

Boysen, MMK ;

Elsner, K ;

Sperling, O ;

Lindhorst, TK .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (22) :4376-4386

[3]

New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting [J].

Chytil, P. ;

Etrych, T. ;

Konak, C. ;

Sirova, M. ;

Mrkvan, T. ;

Boucek, J. ;

Rihova, B. ;

Ulbrich, K. .

JOURNAL OF CONTROLLED RELEASE, 2008, 127 (02) :121-130

[4]

Polymer conjugates as anticancer nanomedicines [J].

Duncan, Ruth .

NATURE REVIEWS CANCER, 2006, 6 (09) :688-701

[5]

Frey Holger, 2002, J Biotechnol, V90, P257, DOI 10.1016/S1389-0352(01)00063-0

[6]

Grinstaff MW, 2002, CHEM-EUR J, V8, P2838, DOI 10.1002/1521-3765(20020703)8:13<2838::AID-CHEM2838>3.0.CO

[7]

2-I

[8]

Polymer therapeutics: Concepts and applications [J].

Haag, R ;

Kratz, F .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (08) :1198-1215

[9]

An approach to glycerol dendrimers and pseudo-dendritic polyglycerols [J].

Haag, R ;

Sunder, A ;

Stumbé, JF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (12) :2954-2955

[10]

HAAG R, 2002, Patent No. 10211664

← 1 2 3 →