Intricate Links between ER Stress and Apoptosis

被引：54

作者：

Madeo, Frank ^{[2
]}

Kroemer, Guido ^{[1
,3
]}

机构：

[1] Inst Gustave Roussy, INSERM, U848, F-94805 Villejuif, France

[2] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[3] Univ Paris 11, F-94270 Le Kremlin Bicetre, France

来源：

MOLECULAR CELL | 2009年 / 33卷 / 06期

关键词：

ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; BAX INHIBITOR-1; CELL-DEATH;

D O I：

10.1016/j.molcel.2009.03.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1 alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

引用

页码：669 / 670

页数：2

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