Tandem Meinwald Rearrangement-Fischer Indolisation: A One-Pot Conversion of Epoxides into Indoles

被引：33

作者：

Donald, James R. ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

SYNLETT | 2009年 / 01期

关键词：

aldehydes; epoxides; indoles; rearrangements; tandem reactions; ALDEHYDES; KETONES; OXIDATION; EFFICIENT; CATALYST; METALLOPORPHYRIN; ISOMERIZATION; CONSTRUCTION; DERIVATIVES;

D O I：

10.1055/s-0028-1087476

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem Sc(OTf)(3)-mediated Meinwald epoxide rearrangement-Fischer indole synthesis is reported. Optimisation and scope and limitation studies are described. In addition, preliminary investigations to develop a telescoped epoxidation-Meinwald rearrangement-Fischer indole sequence are outlined.

引用

页码：59 / 62

页数：4

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