Highly diastereoselective addition of trimethylsilyl cyanide to chiral hydrazones in the presence of Et(2)AlCl

被引:20
作者
Choi, JY [1 ]
Kim, YH [1 ]
机构
[1] KOREA ADV INST SCI & TECHNOL,DEPT CHEM,YUSONG GU,TAEJON 305701,SOUTH KOREA
关键词
D O I
10.1016/0040-4039(96)01780-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Chiral hydrazones, synthesized from (S)-1-amino-2-methoxymethylindoline and aliphatic aldehydes, reacted with trimethylsilyl cyanide in the presence of diethylaluminium chloride in CH2Cl2 at -78 degrees C to give chiral alpha-hydrazinonitriles with high diastereoselectivity (up to 96% de). Copyright (C) 1996 Elsevier Science Ltd.
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页码:7795 / 7796
页数:2
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