Highly diastereoselective addition of trimethylsilyl cyanide to chiral hydrazones in the presence of Et(2)AlCl

被引：20

作者：

Choi, JY ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] KOREA ADV INST SCI & TECHNOL,DEPT CHEM,YUSONG GU,TAEJON 305701,SOUTH KOREA

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 43期

关键词：

D O I：

10.1016/0040-4039(96)01780-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral hydrazones, synthesized from (S)-1-amino-2-methoxymethylindoline and aliphatic aldehydes, reacted with trimethylsilyl cyanide in the presence of diethylaluminium chloride in CH2Cl2 at -78 degrees C to give chiral alpha-hydrazinonitriles with high diastereoselectivity (up to 96% de). Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：7795 / 7796

页数：2

共 10 条

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