Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system

被引：120

作者：

Mortera, Renato ^{[3
]}

Vivero-Escoto, Juan ^{[1
,2
]}

Slowing, Igor I. ^{[1
,2
]}

Garrone, Edoardo ^{[3
]}

Onida, Barbara ^{[3
]}

Lin, Victor S. -Y. ^{[1
,2
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[2] Iowa State Univ, US DOE Ames Lab, Ames, IA 50011 USA

[3] Politecn Torino, Dipartimento Sci Mat & Ingn Chim, I-10129 Turin, Italy

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 22期

基金：

美国国家科学基金会;

关键词：

N-ACETYLCYSTEINE; OXIDATIVE STRESS; GLUTATHIONE; FUNCTIONALIZATION;

D O I：

10.1039/b900559e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mesoporous silica nanoparticle-based intracellular cysteine delivery system that could be induced and regulated by cell-produced natural antioxidants was synthesized.

引用

页码：3219 / 3221

页数：3

共 28 条

[1]

Anderson ME, 1998, CHEM-BIOL INTERACT, V112, P1

[2]

ANDERSON ME, 1987, METHOD ENZYMOL, V143, P313

[3] Stress, inflammation and cardiovascular disease [J].

Black, PH ;

Garbutt, LD .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 2002, 52 (01) :1-23

[4] The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells [J].

Chung, Tsai-Hua ;

Wu, Si-Han ;

Yao, Ming ;

Lu, Chen-Wen ;

Lin, Yu-Shen ;

Hung, Yann ;

Mou, Chung-Yuan ;

Chen, Yao-Chang ;

Huang, Dong-Ming .

BIOMATERIALS, 2007, 28 (19) :2959-2966

[5] Effects of a "supplementation" with antioxidant nutrients on the values of circulating immunoglobulins among women recently mastectomized and treated by chemotherapy [J].

de Carvalho Costa, Maria Jose ;

Lima Ferreira, Maria de Fatima ;

Rios Asciuttia, Luiza Sonia ;

da Silva, Lino Joao ;

Amado Rivera, Maria Amelia ;

Limbach, Stephanie ;

Guilland, Jean-Claude ;

Coelho Costa, Maria de Lourdes ;

Ferreira Soares, Georgia Sousa .

NUTRITION CLINIQUE ET METABOLISME, 2007, 21 (01) :4-8

[6] Oxidative stress and ageing:: is ageing a cysteine deficiency syndrome? [J].

Dröge, W .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1464) :2355-2372

[7] Antioxidant activity of N-acetylcysteine, flavonoids and α-tocopherol on endometrial cells in culture [J].

Estany, S. ;

Palacio, J. R. ;

Barnadas, R. ;

Sabes, M. ;

Iborra, A. ;

Martinez, P. .

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2007, 75 (01) :1-10

[8] Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier [J].

Gilgun-Sherki, Y ;

Melamed, E ;

Offen, D .

NEUROPHARMACOLOGY, 2001, 40 (08) :959-975

[9] Mesoporous silica nanomaterial-based biotechnological and biomedical delivery systems [J].

Giri, Supratim ;

Trewyn, Brian G. ;

Lin, Victor S. Y. .

NANOMEDICINE, 2007, 2 (01) :99-111

[10] Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers [J].

Hong, R ;

Han, G ;

Fernández, JM ;

Kim, BJ ;

Forbes, NS ;

Rotello, VM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (04) :1078-1079

← 1 2 3 →