Time up and go task performance improves after transcranial direct current stimulation in patient affected by Parkinson's disease

被引：53

作者：

Manenti, Rosa ^{[1
]}

Brambilla, Michela ^{[1
]}

Rosini, Sandra ^{[1
]}

Orizio, Italo ^{[1
]}

Ferrari, Clarissa ^{[1
]}

Borroni, Barbara ^{[2
]}

Cotelli, Maria ^{[1
]}

机构：

[1] IRCCS, Ctr San Giovanni Dio Fatebenefratelli, I-25125 Brescia, Italy

[2] Univ Brescia, Ctr Aging Brain & Neurodegenerat Disorders, Neurol Unit, Brescia, Italy

来源：

NEUROSCIENCE LETTERS | 2014年 / 580卷

关键词：

Movement disorders; Executive functions; Non-invasive brain stimulation; Rehabilitation; Cognitive impairment; DORSOLATERAL PREFRONTAL CORTEX; NONINVASIVE BRAIN-STIMULATION; COGNITIVE FUNCTION; MOTOR; WALKING; GAIT; RTMS;

D O I：

10.1016/j.neulet.2014.07.052

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Locomotor disturbances represent one of the major distress in everyday life in people with Parkinson's disease (PD). Timed up and go test (TUG) has been advocated a useful and reliable tool for quantifying locomotor performance. The aim of this study was to assess the effect of anodal transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) during timed up and go test (TUG) in a group of patients with PD. Ten participants underwent two sessions of anodal tDCS (left and right) and one session of placebo tDCS. TUG was performed before and after each tDCS session (anodal or placebo). A significant motor improvement after right DLPFC stimulation vs. placebo stimulation was observed. These results suggest that anodal tDCS can be a relevant tool to modulate walking abilities in PD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：74 / 77

页数：4

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