Activation of hepatitis C virus translation by a liver-specific microRNA

被引：70

作者：

Niepmann, Michael ^{[1
]}

机构：

[1] Univ Giessen, Fac Med, Inst Biochem, D-35392 Giessen, Germany

来源：

CELL CYCLE | 2009年 / 8卷 / 10期

关键词：

miR-122; HCV; translation; activation; regulation; MESSENGER-RNAS; 3'-UNTRANSLATED REGION; IN-VIVO; TARGET; REPLICATION; MIR-122; MECHANISMS; BINDING; IDENTIFICATION; RECOGNITION;

D O I：

10.4161/cc.8.10.8349

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNAs (miRNAs) are involved in the regulation of translation of many mRNAs and affect cell cycle progression, differentiation and metabolism. The liver-specific microRNA-122 (miR-122) contributes to the liver tropism of Hepatitis C Virus (HCV) by accelerating the binding of ribosomes to the viral RNA and thereby stimulating HCV translation. Here, the most recent results on the molecular mechanisms of microRNA action on HCV and the implications for the understanding of translation regulation by microRNAs are discussed.

引用

页码：1473 / 1477

页数：5

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