Antimalarial Drugs as Immune Modulators: New Mechanisms for Old Drugs

被引：103

作者：

An, Jie ^{[1
]}

Minie, Mark ^{[2
]}

Sasaki, Tomikazu ^{[3
]}

Woodward, Joshua J. ^{[4
]}

Elkon, Keith B. ^{[1
,5
]}

机构：

[1] Univ Washington, Dept Med, Div Rheumatol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[3] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[4] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[5] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 68 | 2017年 / 68卷

关键词：

autoimmunity; cGAS; innate immunity; Toll-like receptors; systemic lupus erythematosus; rheumatoid arthritis; CYCLIC GMP-AMP; FERRIPROTOPORPHYRIN-IX; AUTOIMMUNE-DISEASE; STRUCTURAL BIOLOGY; MALARIA VACCINE; DNA-BINDING; IFN-ALPHA; ARTEMISININ; CHLOROQUINE; DISCOVERY;

D O I：

10.1146/annurev-med-043015-123453

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The best known of the naturally occurring antimalarial compounds are quinine, extracted from cinchona bark, and artemisinin (qinghao), extracted from Artemisia annua in China. These and other derivatives are now chemically synthesized and remain the mainstay of therapy to treat malaria. The beneficial effects of several of the antimalarial drugs (AMDs) on clinical features of autoimmune disorders were discovered by chance during World War II. In this review, we discuss the chemistry of AMDs and their mechanisms of action, emphasizing how they may impact multiple pathways of innate immunity. These pathways include Toll-like receptors and the recently described cGAS-STING pathway. Finally, we discuss the current and future impact of AMDs on systemic lupus erythematosus, rheumatoid arthritis, and devastating monogenic disorders (interferonopathies) characterized by expression of type I interferon in the brain.

引用

页码：317 / 330

页数：14

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