Evaluation of tissue perfusion in a rat model of hind-limb muscle ischemia using dynamic contrast-enhanced magnetic resonance imaging

被引：37

作者：

Luo, YP ^{[1
]}

Mohning, KM ^{[1
]}

Hradil, VP ^{[1
]}

Wessale, JL ^{[1
]}

Segreti, JA ^{[1
]}

Nuss, ME ^{[1
]}

Wegner, CD ^{[1
]}

Burke, SE ^{[1
]}

Cox, BF ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2002年 / 16卷 / 03期

关键词：

MRI; contrast enhancement; peripheral vascular disease; muscle perfusion; muscle blood flow;

D O I：

10.1002/jmri.10169

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To evaluate the feasibility of using dynamic contrast enhanced magnetic resonance imaging (MRI) for assessment of muscle perfusion in a rat model of hind-limb ischemia. Materials and Methods: The acute alteration and chronic recovery in muscle perfusion and perfusion reserve after femoral artery ligation were quantified using the maximum Gd-DTPA uptake rate obtained by a T-1-weighted gradient-recalled echo sequence. Radionuclide-labeled microsphere blood flow measurements were performed for comparison with the MR perfusion measurement on a separate set of animals. Results: After femoral artery ligation, a significant reduction in resting muscle perfusion was only observed at 1 hour post-litigation during the 28-day follow up period. Muscle perfusion reserve was severely diminished following the ligation. Despite significant recovery over time, perfusion reserve to the ligated limb reached only 63% of the perfusion capacity in the unaffected limb by 42 days post ligation. A strong correlation (r = 0.86) between MR perfusion and microsphere blood flow measurements was observed for evaluation of relative changes in muscle perfusion. Conclusion: Dynamic contrast-enhanced MRI with Gd-DTPA is useful to assess time-dependant changes in muscle perfusion and perfusion reserve in this hind-limb ischemia model.

引用

页码：277 / 283

页数：7

共 31 条

[1] EFFECT OF PERFUSION ON EXERCISED MUSCLE - MR IMAGING EVALUATION [J].

ARCHER, BT ;

FLECKENSTEIN, JL ;

BERTOCCI, LA ;

HALLER, RG ;

BARKER, B ;

PARKEY, RW ;

PESHOCK, RM .

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1992, 2 (04) :407-413

[2] 1ST-PASS CARDIAC PERFUSION - EVALUATION WITH ULTRAFAST MR IMAGING [J].

ATKINSON, DJ ;

BURSTEIN, D ;

EDELMAN, RR .

RADIOLOGY, 1990, 174 (03) :757-762

[3] AN INVESTIGATION OF ARTERIAL INSUFFICIENCY IN RAT HINDLIMB - A COMBINED P-31-NMR AND BLOODFLOW STUDY [J].

CHALLISS, RAJ ;

HAYES, DJ ;

PETTY, RFH ;

RADDA, GK .

BIOCHEMICAL JOURNAL, 1986, 236 (02) :461-467

[4]

Cooke J P, 1997, Vasc Med, V2, P227

[5] PERFUSION IMAGING [J].

DETRE, JA ;

LEIGH, JS ;

WILLIAMS, DS ;

KORETSKY, AP .

MAGNETIC RESONANCE IN MEDICINE, 1992, 23 (01) :37-45

[6] QUANTIFICATION OF MYOCARDIAL BLOOD-FLOW AND EXTRACELLULAR VOLUMES USING A BOLUS INJECTION OF GD-DTPA - KINETIC MODELING IN CANINE ISCHEMIC DISEASE [J].

DIESBOURG, LD ;

PRATO, FS ;

WISENBERG, G ;

DROST, DJ ;

MARSHALL, TP ;

CARROLL, SE ;

ONEILL, B .

MAGNETIC RESONANCE IN MEDICINE, 1992, 23 (02) :239-253

[7] ISCHEMIC-HEART-DISEASE - ASSESSMENT WITH GADOLINIUM-ENHANCED ULTRAFAST MR-IMAGING AND DIPYRIDAMOLE STRESS [J].

EICHENBERGER, AC ;

SCHUIKI, E ;

KOCHLI, VD ;

AMANN, FW ;

MCKINNON, GC ;

VONSCHULTHESS, GK .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (03) :425-431

[8]

Frank LR, 1999, MAGN RESON MED, V42, P258, DOI 10.1002/(SICI)1522-2594(199908)42:2<258::AID-MRM7>3.0.CO

[9]

2-E

[10] Assessment of tumor microcirculation: A new role of dynamic contrast MR imaging [J].

Griebel, J ;

Mayr, NA ;

deVries, A ;

Knopp, MV ;

Gneiting, T ;

Kremser, C ;

Essig, M ;

Hawighorst, H ;

Lukas, PH ;

Yuh, WTC .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (01) :111-119

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