Fluorescent Polystyrene-Fe3O4 Composite Nanospheres for In Vivo Imaging and Hyperthermia

被引：154

作者：

Shi, Donglu ^{[1
,2
,3
]}

Cho, Hoon Sung ^{[2
]}

Chen, Yan ^{[4
]}

Xu, Hong ^{[5
]}

Gu, Hongchen ^{[5
]}

Lian, Jie ^{[6
]}

Wang, Wei ^{[2
]}

Liu, Guokui ^{[9
]}

Huth, Christopher ^{[2
]}

Wang, Lumin ^{[7
,8
]}

Ewing, Rodney C. ^{[7
,8
]}

Budko, Sergei ^{[10
,11
]}

Pauletti, Giovanni M. ^{[12
]}

Dong, Zhongyun ^{[13
]}

机构：

[1] Tongji Univ, Inst Adv Mat & NanoBiomed, Shanghai 200092, Peoples R China

[2] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA

[3] Shanghai Jiao Tong Univ, Inst Micronanosci & Technol, Shanghai 200240, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai 200031, Peoples R China

[5] Shanghai Jiao Tong Univ, Med X Inst, Shanghai 200030, Peoples R China

[6] Jonsson Engn Ctr, Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA

[7] Univ Michigan, Dept Geol Sci Nucl Engn & Radiol Sci, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

[9] Argonne Natl Lab, Div Chem, Argonne, IL 60439 USA

[10] Iowa State Univ, Ames Lab, Ames, IA 50011 USA

[11] Iowa State Univ, Dept Phys & Astron, Ames, IA 50011 USA

[12] Univ Cincinnati, James L Winkle Coll Pharm, Cincinnati, OH 45267 USA

[13] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH 45221 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 21期

关键词：

QUANTUM DOTS; LIVE CELLS; NANOPARTICLES; TIME;

D O I：

10.1002/adma.200803159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quantum dots (QDs) are immobilized on the surfaces of magnetic Fe3O4-composite nanospheres (MNSs, see figure). The QDs exhibit intense visible-light emission in fluorescence spectroscopy and successfully facilitate, for the first time, in vivo soft-tissue imaging in live mice. The Fe3O4 nanoparticles respond to an external magnetic field by increasing the temperature of the surrounding environment (i.e., hyperthermia), which can be used therapeutically.

引用

页码：2170 / +

页数：5

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