The clinical usefulness of 18-fluorodeoxyglucose positron emission tomography in the differential diagnosis, staging, and response evaluation after concurrent chemoradiotherapy for pancreatic cancer

被引:120
作者
Bang, Seungmin
Chung, Hye Won
Park, Seung Woo
Chung, Jae Bock
Yun, Mijin
Lee, Jong Doo
Song, Si Young
机构
[1] Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol,Inst Gastroenterol, Seoul 120752, South Korea
[2] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea
[3] Yonsei Univ, Coll Med, Dept Nucl Med, Seoul 120752, South Korea
关键词
pancreatic cancer; (18)FDG-PET; CT scan; chronic pancreatitis; differential diagnosis;
D O I
10.1097/01.mcg.0000225672.68852.05
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Goals: The aims of this study were to determine the clinical use of 18-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) in the differential diagnosis of patients with suspected pancreatic cancer and in the determination of tumor response after concurrent chemo radio therapy for pancreatic cancer. Background: Despite advances in diagnostic tools for pancreatic cancer, it is difficult to differentiate pancreatic cancer from mass-forming pancreatitis. Even with current imaging modalities, it is also difficult to assess tumor response to therapeutic intervention. Study: One hundred two patients with suspected pancreatic cancer were selected for this study. Dynamic computerized tomography (CT) scan and (18)FDG-PET were used sequentially to diagnose pancreatic cancer. After diagnostic confirmation their diagnostic yields were compared. We also evaluated the treatment response in 15 patients who underwent chemoradiation therapy with dynamic CT scan and (18)FDG-PET and compared their results. Results: In 93 out of 102 patients, pancreatic cancer was confirmed. (18)FDG-PET showed higher diagnostic accuracy than CT scan (95. 1 % vs. 76.5%). (18)FDG-PET was also superior to CT in the detection of liver metastasis. (18)FDG-PET detected treatment response in 5 out of 15 cases after chemoradiation therapy. whereas CT could not detect any treatment response. Comparing responder and nonresponder, (18)FDG-PET was able to predict significantly different prognosis (399 vs. 233 d, P < 0.05). Conclusions: (18)FDG-PET is a very useful tool in diagnosing pancreatic cancer. (18)FDG-PET may be also used as an adjunct for determining the treatment modality of pancreatic cancer and evaluating tumor response to chemoradiation therapy.
引用
收藏
页码:923 / 929
页数:7
相关论文
共 32 条
  • [1] F-18 FLUORODEOXYGLUCOSE PET IN-VIVO EVALUATION OF PANCREATIC GLUCOSE-METABOLISM FOR DETECTION OF PANCREATIC-CANCER
    BARES, R
    KLEVER, P
    HAUPTMANN, S
    HELLWIG, D
    FASS, J
    CREMERIUS, U
    SCHUMPELICK, V
    MITTERMAYER, C
    BULL, U
    [J]. RADIOLOGY, 1994, 192 (01) : 79 - 86
  • [2] Presumed malignant biliary obstruction despite a normal CT: Data to support pancreatico-duodenectomy (PD).
    Bouvet, M
    Bold, R
    Lee, J
    Pisters, P
    Abbruzzese, J
    Raijman, I
    Charnsangavej, C
    Evans, DB
    [J]. GASTROENTEROLOGY, 1998, 114 (04) : A1380 - A1380
  • [3] Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    Burris, HA
    Moore, MJ
    Andersen, J
    Green, MR
    Rothenberg, ML
    Madiano, MR
    Cripps, MC
    Portenoy, RK
    Storniolo, AM
    Tarassoff, P
    Nelson, R
    Dorr, FA
    Stephens, CD
    VanHoff, DD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (06) : 2403 - 2413
  • [4] PANCREATIC-CANCER VERSUS CHRONIC-PANCREATITIS - DIAGNOSIS WITH CA 19-9 ASSESSMENT, US, CT, AND CT-GUIDED FINE-NEEDLE BIOPSY
    DELMASCHIO, A
    VANZULLI, A
    SIRONI, S
    CASTRUCCI, M
    MELLONE, R
    STAUDACHER, C
    CARLUCCI, M
    ZERBI, A
    PAROLINI, D
    FARAVELLI, A
    CANTABONI, A
    GARANCINI, P
    DICARLO, V
    [J]. RADIOLOGY, 1991, 178 (01) : 95 - 99
  • [5] PANCREATIC DUCTAL ADENOCARCINOMA - DIAGNOSIS AND STAGING WITH DYNAMIC CT
    FREENY, PC
    MARKS, WM
    RYAN, JA
    TRAVERSO, LW
    [J]. RADIOLOGY, 1988, 166 (01) : 125 - 133
  • [6] DIAGNOSIS OF PANCREATIC-CANCER BY 2[F-18]-FLUORO-2-DEOXY-D-GLUCOSE POSITRON EMISSION TOMOGRAPHY
    FRIESS, H
    LANGHANS, J
    EBERT, M
    BEGER, HG
    STOLLFUSS, J
    RESKE, SN
    BUCHLER, MW
    [J]. GUT, 1995, 36 (05) : 771 - 777
  • [7] Fröhlich A, 1999, J NUCL MED, V40, P250
  • [8] Prospective comparison of endoscopic ultrasound and endoscopic retrograde cholangiopancreatography in the preoperative assessment of masses in the pancreatic head
    Glasbrenner, B
    Schwarz, M
    Pauls, S
    Preclik, G
    Beger, HG
    Adler, G
    [J]. DIGESTIVE SURGERY, 2000, 17 (05) : 468 - 474
  • [9] Higashi T, 1997, J NUCL MED, V38, P1337
  • [10] Higashi T, 2002, J NUCL MED, V43, P173