The first synthesis of the bis(indole) marine alkaloid caulersin

被引：39

作者：

Fresneda, PM ^{[1
]}

Molina, P ^{[1
]}

Saez, MA ^{[1
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30071 Murcia, Spain

来源：

SYNLETT | 1999年 / 10期

关键词：

caulersin; marine alkaloid; bis(indole); bis(indolyl)ketone; nitrene insertion;

D O I：

10.1055/s-1999-2903

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis (seven steps) of the bis(indole) marine alkaloid caulersin is described. Construction of the central seven-membered ring is based on a Michael-type addition of the appropriate 2,3'-bis(indolyl)ketone to methylvinylketone followed by intramolecular nucleophilic substitution of the resulting 3-oxoalkylated product.

引用

页码：1651 / 1653

页数：3

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