Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

被引：62

作者：

Wang, Hansong ^{[1
]}

Burnett, Terrilea ^{[1
]}

Kono, Suminori ^{[2
]}

Haiman, Christopher A. ^{[3
,4
]}

Iwasaki, Motoki ^{[5
]}

Wilkens, Lynne R. ^{[1
]}

Loo, Lenora W. M. ^{[1
]}

Van den Berg, David ^{[3
,4
]}

Kolonel, Laurence N. ^{[1
]}

Henderson, Brian E. ^{[3
,4
]}

Keku, Temitope O. ^{[6
]}

Sandler, Robert S. ^{[6
]}

Signorello, Lisa B. ^{[7
,8
,9
]}

Blot, William J. ^{[10
,11
]}

Newcomb, Polly A. ^{[12
]}

Pande, Mala ^{[13
]}

Amos, Christopher I. ^{[14
]}

West, Dee W. ^{[15
]}

Bezieau, Stephane ^{[16
]}

Berndt, Sonja I. ^{[17
]}

Zanke, Brent W. ^{[18
,19
]}

Hsu, Li ^{[12
]}

Lindor, Noralane M. ^{[20
]}

Haile, Robert W. ^{[21
]}

Hopper, John L. ^{[22
]}

Jenkins, Mark A. ^{[22
]}

Gallinger, Steven ^{[23
]}

Casey, Graham ^{[3
,4
]}

Stenzel, Stephanie L. ^{[3
,4
]}

Schumacher, Fredrick R. ^{[3
,4
]}

Peters, Ulrike ^{[12
]}

Gruber, Stephen B. ^{[3
,4
]}

Tsugane, Shoichiro ^{[5
]}

Stram, Daniel O. ^{[3
,4
]}

Le Marchand, Loic ^{[1
]}

机构：

[1] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA

[2] Kyushu Univ, Grad Sch Med Sci, Dept Prevent Med, Fukuoka 8128581, Japan

[3] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[4] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[5] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Tokyo 1040045, Japan

[6] Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Channing Div Network Med, Boston, MA 02115 USA

[9] Dana Farber Harvard Canc Ctr, Boston, MA 02115 USA

[10] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol, Nashville, TN 37235 USA

[11] Int Epidemiol Inst, Rockville, MD 20850 USA

[12] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98124 USA

[13] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Res, Houston, TX 77030 USA

[14] Dartmouth Coll, Geisel Sch Med, Dept Community & Family Med, Lebanon, NH 03755 USA

[15] Canc Prevent Inst Calif, Fremont, CA 94538 USA

[16] CHU Nantes, Serv Genet Med, F-44093 Nantes, France

[17] Natl Canc Inst, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[18] Univ Ottawa, Fac Med, Div Hematol, Ottawa, ON K1J 8M5, Canada

[19] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON K1J 8M5, Canada

[20] Mayo Clin Arizona, Dept Hlth Sci Res, Scottsdale, AZ 85054 USA

[21] Stanford Canc Inst, Stanford, CA 94305 USA

[22] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia

[23] Canc Care Ontario, Toronto, ON M5G 2L3, Canada

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

PROSTATE-CANCER; RISK; METAANALYSIS;

D O I：

10.1038/ncomms5613

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 x 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P = 1.4 x 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

引用

页数：7

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