Learning and memory - Never fear, LTP is hear

被引:22
作者
Malenka, RC
Nicoll, RA
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT CELLULAR & MOL PHARMACOL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
关键词
D O I
10.1038/37472
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hippocampal long-term potentiation (LTP) has long been suspected to be involved in learning and memory, but definitive proof has been hard to come by. Two groups now report, however, that fear conditioning (which is a form of pavlovian conditioning) causes an increase in the strength of synapses in a region of the brain that is associated with learning and memory. Animals were trained to associate a tone with a foot shock, eliciting a response of ‘fear’. After training, this response occurred when the tone was given but the foot shock was not.
引用
收藏
页码:552 / 553
页数:2
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