Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A).

被引：96

作者：

Paterson, I

Keown, LE

机构：

[1] University Chemical Laboratory, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(97)01257-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-36-C-46 subunit 3, containing the F ring of spongistatin 1 (1), was prepared in 12 steps from ketone (R)-7. Key steps include: (i) the boron-mediated anti aldol reaction, 7 --> 9; (ii) the Sharpless AD, 6 --> 13; and(iii) an intramolecular hetero-Michael addition, followed by base-promoted equilibration to give 3. (C) 1997 Elsevier Science Ltd.

引用

页码：5727 / 5730

页数：4

共 37 条

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