Flow Cytometry Applications for the Analysis of Chemokine Receptor Expression and Function

被引：13

作者：

Anselmo, Achille ^{[1
]}

Mazzon, Cristina ^{[1
]}

Borroni, Elena Monica ^{[1
,2
]}

Bonecchi, Raffaella ^{[1
,2
]}

Graham, Gerard J. ^{[3
]}

Locati, Massimo ^{[1
,2
]}

机构：

[1] Humanitas Clin & Res Ctr, I-20089 Milan, Italy

[2] Univ Milan, Dept Med Biotechnol & Translat Med, I-20089 Milan, Italy

[3] Univ Glasgow, Chemokine Res Grp, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

来源：

CYTOMETRY PART A | 2014年 / 85卷 / 04期

基金：

英国惠康基金;

关键词：

flow cytometry; chemokine receptor; antibodies; fluorophores; MONOMERIC RED; T-CELL; D6; IMMUNITY; HIV-1; MONOCYTE; BIOLOGY; INNATE; AGRIN; CCR5;

D O I：

10.1002/cyto.a.22439

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Chemokine receptors play an important role in leukocyte migration, both in physiological and pathological conditions, and the interest in new methodologies for their detection is increasing. In this review, we focused on chemokine receptors detection through flow cytometric approaches, including the use of specific antibodies and fluorescent chemokines, and on approaches aimed at the analysis of their functions, from intracellular trafficking to signaling activities. (c) 2014 International Society for Advancement of Cytometry

引用

页码：292 / 301

页数：10

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