Selective plasma hydrolysis of glucocorticoid γ-lactones and cyclic carbonates by the enzyme paraoxonase:: An ideal plasma inactivation mechanism

被引：166

作者：

Biggadike, K

Angell, RM

Burgess, CM

Farrell, RM

Hancock, AP

Harker, AJ

Irving, WR

Ioannou, C

Procopiou, PA

Shaw, RE

Solanke, YE

Singh, OMP

Snowden, MA

Stubbs, RJ

Walton, S

Weston, HE

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Chem Unit, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[2] Glaxo Wellcome Res & Dev Ltd, Enzyme Pharmacol Unit, Med Res Ctr, Stevenage SG1 2NY, Herts, England

[3] Glaxo Wellcome Res & Dev Ltd, Biomet Discovery & Prot Sci Unit, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 43卷 / 01期

关键词：

D O I：

10.1021/jm990436t

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：19 / 21

页数：3

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