Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses

被引：114

作者：

Wang, SD ^{[1
]}

Chen, LP ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Coll Med, Ctr Canc, Dept Immunol, Rochester, MN 55905 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 08期

关键词：

B7; CD28; costimulation; T cell activation;

D O I：

10.1016/j.micinf.2004.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Co-signaling molecules in the B7-CD28 family have been intensively studied over the past decade and have brought much excitement to the field of immune regulation. The discovery of new functions for the classical pathways CD80/CD86/CD28/CTLA-4 and the identification of novel pathways of the family. including B7-H1/B7-DC/PD-1, B7-H2/ICOS, B7-H3, B7-H4 and BTLA, are greatly broadening our understanding, of the control of T cell-mediated immune responses and tolerance. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：759 / 766

页数：8

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